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Giant renal angiomyolipoma with tuberous sclerosis complex

Ouyan SHI PhD, Guodong XU BM, Chunxiang WANG BM,

《医学前沿（英文）》 2009年第3卷第4期页码 495-498 doi: 10.1007/s11684-009-0068-8

摘要： Though rare, angiomyolipomas (AMLs) are the most common mesenchymal tumors of kidney. In general, AMLs can always be associated with two conditions affecting other organ systems: tuberous sclerosis complex (TSC) and sporadic lymphangioleiomyomatosis. This article presents a case of renal AML occurring in a 14-year-old girl with a definite diagnosis of TSC. She had been diagnosed with TSC at the age of three, and a schedule for close observation was disobeyed. At this time, she underwent a series of examinations: physical examination, ultrasonography, angiography, computed tomography (CT), and magnetic resonance imaging (MRI) scans. The physical examination showed adenoma sebaceum in a butterfly paranasal distribution, and a mass was palpated in the left upper quadrant. There were no neurological deficits. Imaging studies (including ultrasonography, angiography, CT, and MRI) of the abdomen showed a large heterogeneous mass arising from the left kidney. Partial nephrectomy was performed. The pathological diagnosis was hemorrhagic renal AML. No recurrence was found in the three-year follow-up. We concluded that schedule of close observation on patients with TSC should be strictly abided by for the high morbidity of AMLs. The specific risks of renal AMLs are spontaneous hemorrhage and rupture. Treatment options for AMLs include conservative and interventional (total/partial nephrectomy, cryoptherapy, and embolization) treatments.

关键词： renal angiomyolipoma tuberous sclerosis complex hemorrhage

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Association of gene variants with juvenile amyotrophic lateral sclerosis

《医学前沿（英文）》 doi: 10.1007/s11684-023-1005-y

摘要： Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons, and it demonstrates high clinical heterogeneity and complex genetic architecture. A variation within TRMT2B (c.1356G>T; p.K452N) was identified to be associated with ALS in a family comprising two patients with juvenile ALS (JALS). Two missense variations and one splicing variation were identified in 10 patients with ALS in a cohort with 910 patients with ALS, and three more variants were identified in a public ALS database including 3317 patients with ALS. A decreased number of mitochondria, swollen mitochondria, lower expression of ND1, decreased mitochondrial complex I activities, lower mitochondrial aerobic respiration, and a high level of ROS were observed functionally in patient-originated lymphoblastoid cell lines and TRMT2B interfering HEK293 cells. Further, TRMT2B variations overexpression cells also displayed decreased ND1. In conclusion, a novel JALS-associated gene called TRMT2B was identified, thus broadening the clinical and genetic spectrum of ALS.

关键词： TRMT2B amyotrophic lateral sclerosis mitochondrial complex I tRNA methylation reactive oxygen species

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Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker

《医学前沿（英文）》 2022年第16卷第5期页码 723-735 doi: 10.1007/s11684-021-0905-y

摘要： Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. At present, no definite ALS biomarkers are available. In this study, exosomes from the plasma of patients with ALS and healthy controls were extracted, and differentially expressed exosomal proteins were compared. Among them, the expression of exosomal coronin-1a (CORO1A) was 5.3-fold higher than that in the controls. CORO1A increased with disease progression at a certain proportion in the plasma of patients with ALS and in the spinal cord of ALS mice. CORO1A was also overexpressed in NSC-34 motor neuron-like cells, and apoptosis, oxidative stress, and autophagic protein expression were evaluated. CORO1A overexpression resulted in increased apoptosis and oxidative stress, overactivated autophagy, and hindered the formation of autolysosomes. Moreover, CORO1A activated Ca²⁺-dependent phosphatase calcineurin, thereby blocking the fusion of autophagosomes and lysosomes. The inhibition of calcineurin activation by cyclosporin A reversed the damaged autolysosomes. In conclusion, the role of CORO1A in ALS pathogenesis was discovered, potentially affecting the disease onset and progression by blocking autophagic flux. Therefore, CORO1A might be a potential biomarker and therapeutic target for ALS.

关键词： amyotrophic lateral sclerosis coronin-1a autophagy pathogenesis

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GID complex regulates the differentiation of neural stem cells by destabilizing TET2

《医学前沿（英文）》 doi: 10.1007/s11684-023-1007-9

摘要： Brain development requires a delicate balance between self-renewal and differentiation in neural stem cells (NSC), which rely on the precise regulation of gene expression. Ten-eleven translocation 2 (TET2) modulates gene expression by the hydroxymethylation of 5-methylcytosine in DNA as an important epigenetic factor and participates in the neuronal differentiation. Yet, the regulation of TET2 in the process of neuronal differentiation remains unknown. Here, the protein level of TET2 was reduced by the ubiquitin-proteasome pathway during NSC differentiation, in contrast to mRNA level. We identified that TET2 physically interacts with the core subunits of the glucose-induced degradation-deficient (GID) ubiquitin ligase complex, an evolutionarily conserved ubiquitin ligase complex and is ubiquitinated by itself. The protein levels of GID complex subunits increased reciprocally with TET2 level upon NSC differentiation. The silencing of the core subunits of the GID complex, including WDR26 and ARMC8, attenuated the ubiquitination and degradation of TET2, increased the global 5-hydroxymethylcytosine levels, and promoted the differentiation of the NSC. TET2 level increased in the brain of the Wdr26^+/− mice. Our results illustrated that the GID complex negatively regulates TET2 protein stability, further modulates NSC differentiation, and represents a novel regulatory mechanism involved in brain development.

关键词： TET2 GID complex neural stem cells differentiation of neurons

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Footholds optimization for legged robots walking on complex terrain

《机械工程前沿（英文）》 2023年第18卷第2期 doi: 10.1007/s11465-022-0742-y

摘要： This paper proposes a novel continuous footholds optimization method for legged robots to expand their walking ability on complex terrains. The algorithm can efficiently run onboard and online by using terrain perception information to protect the robot against slipping or tripping on the edge of obstacles, and to improve its stability and safety when walking on complex terrain. By relying on the depth camera installed on the robot and obtaining the terrain heightmap, the algorithm converts the discrete grid heightmap into a continuous costmap. Then, it constructs an optimization function combined with the robot’s state information to select the next footholds and generate the motion trajectory to control the robot’s locomotion. Compared with most existing footholds selection algorithms that rely on discrete enumeration search, as far as we know, the proposed algorithm is the first to use a continuous optimization method. We successfully implemented the algorithm on a hexapod robot, and verified its feasibility in a walking experiment on a complex terrain.

关键词： footholds optimization legged robot complex terrain adapting hexapod robot locomotion control

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Special issue: Reliability management of complex system

《工程管理前沿（英文）》 2021年第8卷第4期页码 477-479 doi: 10.1007/s42524-021-0175-z

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Independent cover meshless particle method for complex geotechnical engineering

Jianqiu WU, Yongchang CAI

《结构与土木工程前沿（英文）》 2018年第12卷第4期页码 515-526 doi: 10.1007/s11709-017-0428-4

摘要： A new Independent Cover Meshless Particle (ICMP) method is proposed for the analysis of complex geotechnical engineering. In the ICMP method, the independent rectangular cover regardless of the shape of the analysis model is employed as the influence domain of each discrete node, the general polynomial is employed as the meshless interpolation function of the independent nodal cover, and the Cartesian Transformation Method (CTM) is used for the numerical integration of the nodal covers cut by material interfaces, joints, cracks and faults. The present method has a simple formulation and a low computational cost, and is easy for the numerical analysis and modeling of complex geotechnical engineering. Several typical numerical examples are presented to demonstrate the accuracy and robustness of the proposed method.

关键词： meshless method particle method independent cover CTM geotechnical engineering

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Forecast method for used number of parts and components based on complex network

LIU Fu-yun, QI Guo-ning, YANG Qing-hai

《机械工程前沿（英文）》 2006年第1卷第4期页码 479-484 doi: 10.1007/s11465-006-0064-5

摘要： Applying directed complex network to model the main structure of a product family, according to in-degree bi-logarithmic coordinate distribution curve and distribution rule of nodes of the network, in-degree evolving rule of nodes of the network is presented and analytic expression of in-degree probability density of nodes is derived. Through the analysis of the relation between existing kinds of components and existing product numbers, an expression of the relation between kinds of components and product numbers is derived. A forecast method for the increment of component numbers and parts based on the increment of products is presented. As an example, the component numbers of an industrial steam turbine product family is forecasted, forecast result verified and forecast error analyzed.

关键词： complex network industrial component analytic expression forecast

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Cationic organobismuth complex as an effective catalyst for conversion of CO

Xiaowen ZHANG, Weili DAI, Shuangfeng YIN, Shenglian LUO, Chak-Tong AU

《环境科学与工程前沿（英文）》 2009年第3卷第1期页码 32-37 doi: 10.1007/s11783-008-0068-y

摘要： In order to achieve high-efficiency conversion of CO into valuable chemicals, and to exploit new applications of organobismuth compounds, cationic organobismuth complex with 5,6,7,12-tetrahydrodibenz[c,f] azabismocine framework was examined for the first time for the coupling of CO into cyclic carbonates, using terminal epoxides as substrates and tetrabutylammonium halide as co-catalyst in a solvent-free environment under mild conditions. It is shown that the catalyst exhibited high activity and selectivity for the coupling reaction of CO with a wide range of terminal epoxide. The selectivity of propylene carbonates could reach 100%, and the maximum turnover frequency was up to 10740 h at 120°C and 3 MPa CO pressure when tetrabutylammonium iodide was used as co-catalyst. Moreover, the catalyst is environment friendly, resistant to air and water, and can be readily reused and recycled without any loss of activity, demonstrating a potential in industrial application.

关键词： cationic organobismuth complex terminal epoxide carbon dioxide coupling cyclic carbonate

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Amino acid promoted hydrogen battery system using Mn-pincer complex for reversible CO hydrogenation to

《能源前沿（英文）》 2022年第16卷第5期页码 697-699 doi: 10.1007/s11708-022-0843-7

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Redox reactions of iron and manganese oxides in complex systems

Jianzhi Huang, Huichun Zhang

《环境科学与工程前沿（英文）》 2020年第14卷第5期 doi: 10.1007/s11783-020-1255-8

摘要： • Mechanisms of redox reactions of Fe- and Mn-oxides were discussed. • Oxidative reactions of Mn- and Fe-oxides in complex systems were reviewed. • Reductive reaction of Fe(II)/iron oxides in complex systems was examined. • Future research on examining the redox reactivity in complex systems was suggested. Conspectus Redox reactions of Fe- and Mn-oxides play important roles in the fate and transformation of many contaminants in natural environments. Due to experimental and analytical challenges associated with complex environments, there has been a limited understanding of the reaction kinetics and mechanisms in actual environmental systems, and most of the studies so far have only focused on simple model systems. To bridge the gap between simple model systems and complex environmental systems, it is necessary to increase the complexity of model systems and examine both the involved interaction mechanisms and how the interactions affected contaminant transformation. In this Account, we primarily focused on (1) the oxidative reactivity of Mn- and Fe-oxides and (2) the reductive reactivity of Fe(II)/iron oxides in complex model systems toward contaminant degradation. The effects of common metal ions such as Mn2+ , Ca2+, Ni2+, Cr3+ and Cu2+, ligands such as small anionic ligands and natural organic matter (NOM), and second metal oxides such as Al, Si and Ti oxides on the redox reactivity of the systems are briefly summarized.

关键词： Iron oxides manganese oxides reduction oxidation complex systems reaction kinetics and mechanisms

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A driving pulse edge modulation technique and its complex programming logic devices implementation

Xiao CHEN,Dong-chang QU,Yong GUO,Guo-zhu CHEN

《信息与电子工程前沿（英文）》 2015年第16卷第12期页码 1088-1098 doi: 10.1631/FITEE.1500111

摘要： With the continual increase in switching speed and rating of power semiconductors, the switching voltage spike becomes a serious problem. This paper describes a new technique of driving pulse edge modulation for insulated gate bipolar transistors (IGBTs). By modulating the density and width of the pulse trains, without regulating the hardware circuit, the slope of the gate driving voltage is controlled to change the switching speed. This technique is used in the driving circuit based on complex programmable logic devices (CPLDs), and the switching voltage spike of IGBTs can be restrained through software, which is easier and more flexible to adjust. Experimental results demonstrate the effectiveness and practicability of the proposed method.

关键词： Driving pulse edge modulation Switching voltage spike Complex programmable logic device (CPLD) Active gate drive

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Percolation-based health management of complex traffic systems

《工程管理前沿（英文）》 2021年第8卷第4期页码 557-571 doi: 10.1007/s42524-021-0174-0

摘要： System health management, which aims to ensure the safe and efficient operation of systems by reducing uncertain risks and cascading failures during their lifetime, is proposed for complex transportation systems and other critical infrastructures, especially under the background of the New Infrastructure Projects launched in China. Previous studies proposed numerous approaches to evaluate or improve traffic reliability or efficiency. Nevertheless, most existing studies neglected the core failure mechanism (i.e., spatio–temporal propagation of traffic congestion). In this article, we review existing studies on traffic reliability management and propose a health management framework covering the entire traffic congestion lifetime, from emergence, evolution to dissipation, based on the study of core failure modes with percolation theory. Aiming to be “reliable, invulnerable, resilient, potential, and active”, our proposed traffic health management framework includes modeling, evaluation, diagnosis, and improvement. Our proposed framework may shed light on traffic management for megacities and urban agglomerations around the world. This new approach may offer innovative insights for systems science and engineering in future intelligent infrastructure management.

关键词： traffic health health management critical infrastructure systems science and engineering

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Research Efforts and Fruits of Complex Engineering Management

Ji-Shan He

《工程管理前沿（英文）》 2015年第2卷第1期页码 1-1 doi: 10.15302/J-FEM-2015001

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Multiple damage detection in complex bridges based on strain energy extracted from single point measurement

Alireza ARABHA NAJAFABADI, Farhad DANESHJOO, Hamid Reza AHMADI

《结构与土木工程前沿（英文）》 2020年第14卷第3期页码 722-730 doi: 10.1007/s11709-020-0624-5

摘要： Strain Energy of the structure can be changed with the damage at the damage location. The accurate detection of the damage location using this index in a force system is dependent on the degree of accuracy in determining the structure deformation function before and after damage. The use of modal-based methods to identify damage in complex bridges is always associated with problems due to the need to consider the effects of higher modes and the adverse effect of operational conditions on the extraction of structural modal parameters. In this paper, the deformation of the structure was determined by the concept of influence line using the Betti-Maxwell theory. Then two damage detection indicators were developed based on strain energy variations. These indices were presented separately for bending and torsion changes. Finite element analysis of a five-span concrete curved bridge was done to validate the stated methods. Damage was simulated by decreasing stiffness at different sections of the deck. The response regarding displacement of a point on the deck was measured along each span by passing a moving load on the bridge at very low speeds. Indicators of the strain energy extracted from displacement influence line and the strain energy extracted from the rotational displacement influence line (SERIL) were calculated for the studied bridge. The results show that the proposed methods have well identified the location of the damage by significantly reducing the number of sensors required to record the response. Also, the location of symmetric damages is detected with high resolution using SERIL.

关键词： damage detection strain energy influence line complex bridges rotation displacement